Modular Pyridinyl Peptide Ligands in Asymmetric Catalysis: Enantioselective Synthesis of Quaternary Carbon Atoms Through Copper-Catalyzed Allylic Substitutions

2001 ◽  
Vol 40 (8) ◽  
pp. 1456-1460 ◽  
Author(s):  
Courtney A. Luchaco-Cullis ◽  
Hirotake Mizutani ◽  
Kerry E. Murphy ◽  
Amir H. Hoveyda
Keyword(s):  
Asymmetric Catalysis ◽  
Peptide Ligands ◽  
Enantioselective Synthesis ◽  
Quaternary Carbon ◽  
Allylic Substitutions

Novel Chiral Ligands for Palladium-catalyzed Asymmetric Allylic Alkylation/ Asymmetric Tsuji-Trost Reaction: A Review

2019 ◽  
Vol 23 (11) ◽  
pp. 1168-1213 ◽  
Author(s):  
Samar Noreen ◽  
Ameer Fawad Zahoor ◽  
Sajjad Ahmad ◽  
Irum Shahzadi ◽  
Ali Irfan ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Enantioselective Synthesis ◽  
Chiral Ligands ◽  
Allylic Alkylation ◽  
Research Groups ◽  
Asymmetric Allylic Alkylation ◽  
Catalytic Potential ◽  
Long Time ◽  
Palladium Catalyzed ◽  
Alkylation Reactions

Background: Asymmetric catalysis holds a prestigious role in organic syntheses since a long time and chiral inductors such as ligands have been used to achieve the utmost desired results at this pitch. The asymmetric version of Tsuji-Trost allylation has played a crucial role in enantioselective synthesis. Various chiral ligands have been known for Pdcatalyzed Asymmetric Allylic Alkylation (AAA) reactions and exhibited excellent catalytic potential. The use of chiral ligands as asymmetric inductors has widened the scope of Tsuji-Trost allylic alkylation reactions. Conclusion: Therefore, in this review article, a variety of chiral inductors or ligands have been focused for palladium catalyzed asymmetric allylic alkylation (Tsuji-Trost allylation) and in this regard, recently reported literature (2013-2017) has been described. The use of ligands causes the induction of enantiodiscrimination to the allylated products, therefore, the syntheses of various kinds of ligands have been targeted by many research groups to employ in Pd-catalyzed AAA reactions.

scholarly journals Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides

Synlett ◽  
2018 ◽  
Vol 30 (04) ◽  
pp. 483-487 ◽  
Author(s):  
Shuo Tong ◽  
Mei-Xiang Wang
Keyword(s):  
Phosphoric Acid ◽  
Asymmetric Catalysis ◽  
Nucleophilic Addition ◽  
Addition Reaction ◽  
Enantioselective Synthesis ◽  
Chiral Phosphoric Acid ◽  
Substrate Engineering ◽  
Nucleophilic Addition Reaction ◽  
Engineering Strategy ◽  
Acid Catalyzed

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

Regio‐ and Enantioselective Synthesis of Sulfone‐Bearing Quaternary Carbon Stereocenters by Pd‐Catalyzed Allylic Substitution

2019 ◽  
Vol 132 (3) ◽  
pp. 1356-1361 ◽  
Author(s):  
Ajmal Khan ◽  
Heng Zhao ◽  
Meina Zhang ◽  
Shahid Khan ◽  
Depeng Zhao
Keyword(s):  
Enantioselective Synthesis ◽  
Allylic Substitution ◽  
Quaternary Carbon

Deconjugated butenolide: a versatile building block for asymmetric catalysis

2020 ◽  
Vol 49 (18) ◽  
pp. 6755-6788 ◽  
Author(s):  
Abhijnan Ray Choudhury ◽  
Santanu Mukherjee
Keyword(s):  
Asymmetric Catalysis ◽  
Building Block ◽  
Enantioselective Synthesis ◽  
Asymmetric Reactions ◽  
Comprehensive Overview ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Reactions

Deconjugated butenolides have emerged as a popular synthon for the enantioselective synthesis of γ-lactones. This review provides a comprehensive overview on the catalytic asymmetric reactions of deconjugated butenolides reported till date.

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